Here’s how PIK3CA mutations can cause these conditions
The PIK3CA mutation is present at various levels in different cells and does not affect all cells in the body. As a result, PROS symptoms may occur only in certain parts of the body and affect those body parts in different amounts. Your doctor may call this mosaicism.
Explore this interactive video to learn about the connection between the PIK3CA mutation and your specific PROS condition
KTS (Klippel-Trenaunay Syndrome)
CLOVES syndrome (Congenital Lipomatous Overgrowth, Vascular malformations, Epidermal nevi, Scoliosis/skeletal and spinal)
ILM (Isolated Lymphatic Malformation)
MCAP or M-CM (Megalencephaly-Capillary Malformation)
HME (HemiMegalEncephaly)/DMEG (Dysplastic MEGalencephaly)/Focal cortical dysplasia type II
HHML (HemiHyperplasia-Multiple Lipomatosis)
FIL (Facial Infiltrating Lipomatosis)
FAVA (FibroAdipose Vascular Anomaly)
Macrodactyly
Muscular HH (HemiHyperplasia)
FAO (FibroAdipose hyperplasia or Overgrowth)
CLAPO syndrome (Capillary malformation of the lower lip, Lymphatic malformation of the face and neck, Asymmetry of the face and limbs, and Partial or generalized Overgrowth)
Epidermal nevus, benign lichenoid keratosis, or seborrheic keratosis
Other conditions may be identified and characterized as PROS. Talk to your doctor to find out if your condition is a PROS condition