Patient images from left to right by row: FAVA, CLOVES syndrome (top row); FIL (middle row); CLOVES syndrome, FAVA (bottom row).
 
Patient images from left to right by row: FIL (top row); MCAP/M-CM, CLOVES syndrome (middle row); CLOVES syndrome (bottom row).
 
Patient images from left to right by row: CLOVES syndrome, MCAP/M-CM (top row); MCAP/M-CM (middle row); MCAP/M-CM, FAVA (bottom row).
 

Different conditions, one root cause: PIK3CA mutations

Many conditions share the same common cause—PIK3CA mutations. As a result, these conditions are being classified as PIK3CA-Related Overgrowth Spectrum, or PROS.

Learn more

Different conditions, one root cause: PIK3CA mutations

Many conditions share the same common cause—PIK3CA mutations. As a result, these conditions are being classified as PIK3CA-Related Overgrowth Spectrum, or PROS.

Learn more
 
Patient images from left to right by row: MCAP/M-CM, CLOVES syndrome, CLOVES syndrome (top row); MCAP/M-CM, MCAP/M-CM, FAVA, CLOVES syndrome (bottom row).
 
Patient images from left to right by row: CLOVES syndrome, MCAP/M-CM (top row); FAVA, FIL, CLOVES syndrome (bottom row).
 
Patient images from left to right by row: FAVA, FIL, FAVA (top row); CLOVES syndrome, CLOVES syndrome (bottom row).
 

Different conditions, one root cause: PIK3CA mutations

Many conditions share the same common cause—PIK3CA mutations. As a result, these conditions are being classified as PIK3CA-Related Overgrowth Spectrum, or PROS.

Learn more

Explore the cause of PROS conditions

Watch this interactive video to learn more about PIK3CA mutations in PROS.

Hear from families affected by PROS

Five people share what they want others to know about living with PROS.

 

Find more information below

Discover more about PIK3CA mutations in PROS Learn about PIK3CA mutations and PROS conditions Understand how PROS is diagnosed Current management for PROS symptoms Explore tools to help you talk to others about PROS Access useful resources

PIK3CA-Related Overgrowth Spectrum, or PROS, conditions:

  • KTS (Klippel-Trenaunay Syndrome)
  • CLOVES syndrome (Congenital Lipomatous Overgrowth, Vascular malformations, Epidermal nevi, Scoliosis/skeletal and spinal)
  • ILM (Isolated Lymphatic Malformation)
  • MCAP or M-CM (Megalencephaly-Capillary Malformation)
  • HME (HemiMegalEncephaly)/DMEG (Dysplastic MEGalencephaly)/Focal cortical dysplasia type II
  • HHML (HemiHyperplasia-Multiple Lipomatosis)
  • FIL (Facial Infiltrating Lipomatosis)
  • FAVA (FibroAdipose Vascular Anomaly)
  • Macrodactyly
  • Muscular HH (HemiHyperplasia)
  • FAO (FibroAdipose hyperplasia or Overgrowth)
  • CLAPO syndrome (Capillary malformation of the lower lip, Lymphatic malformation of the face and neck, Asymmetry of the face and limbs, and Partial or generalized Overgrowth)
  • Epidermal nevus, benign lichenoid keratosis, or seborrheic keratosis
  • Other conditions may be identified and characterized as PROS. Talk to your doctor to find out if your condition is a PROS condition
Learn more

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