PIK3CA-Related Overgrowth Spectrum, or PROS, conditions:

• KTS (Klippel-Trenaunay Syndrome)
• CLOVES syndrome (Congenital Lipomatous Overgrowth, Vascular malformations, Epidermal nevi, Scoliosis/skeletal and spinal)
• ILM (Isolated Lymphatic Malformation)
• MCAP or M-CM (Megalencephaly-Capillary Malformation)
• HME (HemiMegalEncephaly)/DMEG (Dysplastic MEGalencephaly)/Focal cortical dysplasia type II
• HHML (HemiHyperplasia-Multiple Lipomatosis)
• FIL (Facial Infiltrating Lipomatosis)
• FAVA (FibroAdipose Vascular Anomaly)
• Macrodactyly
• Muscular HH (HemiHyperplasia)
• FAO (FibroAdipose hyperplasia or Overgrowth)
• CLAPO syndrome (Capillary malformation of the lower lip, Lymphatic malformation of the face and neck, Asymmetry of the face and limbs, and Partial or generalized Overgrowth)
• Epidermal nevus, benign lichenoid keratosis, or seborrheic keratosis
• Other conditions may be identified and characterized as PROS