Different conditions, one root cause
Many abnormal growth and vascular malformations, including lymphatic conditions, are caused by PIK3CA mutations, meaning that part of the DNA known as the “PIK3CA gene” is abnormal and isn’t working correctly. Because these disorders share this common gene mutation, they were grouped together under the name PIK3CA-Related Overgrowth Spectrum, or “PROS” for short.
You or someone you care for may have been diagnosed recently with one of the following conditions, which may be associated with PIK3CA mutations: